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Endothelial function is a marker of atherogenic risk. This study investigated whether supplementing a weight-loss dietary intervention with physical activity attenuates endothelial dysfunction. Overweight and obese women (n = 106, weight = 73 +/- 10 kg, mean +/- SD) were randomly assigned to 1 of 4 groups: dietary intervention (n = 29), dietary intervention plus physical activity (n = 27), dietary intervention plus aerobic exercise (n = 30) or control (n = 20). At baseline and after a weight-loss dietary intervention, endothelial function was assessed by flow-mediated dilation (FMD) and resistance to vascular occlusion (RVD). After a dietary intervention, FMD increased in all groups (control: -0.33 +/- 2.26%, n = 20, p = 0.02; dietary intervention: +1.25 +/- 1.64%, n = 29, p = 0.005; dietary intervention plus physical activity: +1.37 +/- 1.67%, n = 27, p = 0.001; and dietary intervention plus aerobic exercise: +1.62 +/- 2.26%, n = 30, p = 0.001). However, after weight-loss intervention, RVD decreased in all groups (control: -0.47 +/- 4.15%, n = 21, p = 0.03; dietary intervention: -1.77 +/- 3.83%, n = 31, p = 0.01; dietary intervention plus physical activity: -2.30 +/- 4.17%, n = 27, p = 0.002; and dietary intervention plus aerobic exercise: -1.92 +/- 4.47%, n = 28, p = 0.004). The percentage of patients with abnormal

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